元件指南

VectorBuilder提供了許多常用的載體元件，可供用戶在設計載體時(sh計線í)進(jìn)行選擇。下表按類型提供了這們紙(zhè)些常用元件的詳細信息。

姓名	描述	Application Notes	References	序列
CD3zeta	Intracellular domain of the 爸睡T cell receptor-CD3ζ chain	Acts as a stimulatory molecule for act照為ivating T cell-mediated i來銀mmune response.	Cell. 64:891 (1991); Nat Rev Immunol. 2:512 (2002); WO2014055771A1	View

姓名	描述	Application Notes	References	序列
CD28	CD28 intracellula山遠r costimulatory domain	Improves overall survival, prolifer議工ation and persistence of activat報林ed CAR-T cells.	Nat Biotechnol. 20:70 我城(2002); J Immunother. 32:689 (2009); WO2014055771A1	View
4-1BB	4-1BB intracellular costimulatory dom分醫ain	Improves overall su信行rvival, proliferation and術說 persistence of activated CAR-訊他T cells; further enhances cyto路筆toxicity and durability w藍內hen used in combination內答 with CD28.	Leukemia. 18:676 (從森2004); Mol Ther. 17:14北著53 (2009); EP2904106A2	View