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技術資訊
Research Trend
AAVs usher in the ne術還w era of Gene Therapy
Adeno-associated virus (AAV), initi到術ally discovered as a c山舞ontaminant of adenovir靜可us preparations (1), is the新爸 choice vehicle for gene the愛鐘rapy due to its ability to transduce pr熱公oliferating and non-dividing 關服cells with no known 你短pathogenicity to一一 humans. As...
Research Trend
AAV – The king o地兵f viral vectors?
Adeno-associated viru知如s (AAV) has recently been surging in p冷下opularity as a vector sys一筆tem. The recent w人區ave of gene therapy succ通裡esses and powerful new ge票國nome editing technologies, such as CRIS笑可PR/Cas9, have increased p拿我ublic and scientific 又科awareness of t...
Research Trend
Vectors on the br亮跳ain
The nervous system presents several un作房ique challenges that make it a difficul綠身t system to study拿還 experimentally. At a structura花和l level, the brain has a 錯秒complexity that is orders of magni討到tude greater than other organs, an員兒d even the peripheral nervou煙火s s...
Research Trend
Optogenetics in the clinic
Ever since the cloning of channelrhodop她東sin-2 (ChR2), the民姐re has been an explosion科光 of interest in applying o費妹ptogenetic methods to all aspects of n喝來euroscience1. Initially, ChR時相2 was used to contro些呢l neuronal activity in vitro2,3, an線歌d shortly thereafte唱生r in...
Research Trend
Lentivirus “cure”金服 for an ALD
For decades, new innova懂就tions in stem cell biology and geneti為銀c manipulation have嗎拍 driven a wave of proposed treatments b理到ased on these technologies. Althoug輛要h there has been 森資intense speculation a下要nd expectation ab站大out when and how these method聽嗎s will finall...
Latest Discovery
Treating alcoholism with gene therap醫廠y
Alcoholism is a complex disease 很她affecting hundreds of millions of peopl長討e worldwide1. Despite 光兒having devastating consequence知亮s on physical and ment白如al health, and indirectly im遠如pacting families and society,靜問 treatment options are limited and很術 often ineffec...
Research Trend
In vivo reprogramming with viral vecto微火rs
Although multicellular organisms are討年 made up of many cell ty雨紙pes, all with essen村電tially identical genome我土s, cells rarely interconver湖務t between cell types. Once 短不a cell acquires a specific cel內路l fate, it generally d做但oes not assume 兵坐the phenotype of an altern快吧ate cell type....
Research Trend
shRNA screens lead to major disc愛門overies
Loss-of-function screening志下 using shRNA libraries is a pow公從erful way to identify genes 女房involved in almost an是笑y biological process. Over白姐 the past decade, sh現嗎RNA screens, both in v輛上ivo and in cell cu志話lture systems, have ge地秒nerated many important discoveri樹物es...
Research Trend
Controlling when and where: 理文conditional and inducible gene expres嗎在sion
In the early days of enginee業好red animal models,人美 simple knockout and transgenic mic答湖e were used to e行會xamine gene function. Researchers began劇他 to dissect the秒是 roles of individual genes by studyin人動g phenotypes of m樂我ice lacking or ov線就erexpressing specific gene月不s...
Research Trend
Optogenetics: light-control of gene爸跳s, pathways, and cells
Optogenenetics refers to a family of 視技techniques which allow modulation 科雪of biological processes using light綠子. Over the past 12 線麗years, optogenetics has revolutio媽近nized neuroscience and is now e秒錢xpanding to impact many fiel木子ds of biology. There刀生 are now...
Breaking News
CRISPR causes unexpected and widesprea票媽d mutations in vivo
Nuclease-mediated genome ed請人iting, using TALEN or CRISPR/笑器Cas9, has exploded on們習to the scene in recent years, with事林 hundreds of research papers an日頻d patents being published. These t林黃echnologies hold great pro他場mise for treating a wide range of di區匠seases by...
Latest Discovery
CRISPR-based unicellular computer
A major goal of synthetic biology i雨有s to design and build digital genetic 器船circuits inside ce員農lls, effectivel年銀y programming cellular慢草 functions. Achieved this could all村雨ow living cells to be en地村gineered to perform deci喝遠sion-making tasks, simila議舊r to computer..好那.
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